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Amiloride protects against pentylenetetrazole‐induced kindling in mice
Author(s) -
Ali Atif,
Ahmad Farhan Jalees,
Pillai Krishna Kolappa,
Vohora Divya
Publication year - 2005
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706291
Subject(s) - amiloride , kindling , pharmacology , medicine , pentylenetetrazol , epilepsy , anticonvulsant , sodium , chemistry , psychiatry , organic chemistry
1 This study was performed to investigate whether or not amiloride, a sodium–hydrogen exchanger (NHE) inhibitor, can protect against seizure development of pentylenetetrazole (PTZ)‐induced kindling in mice. 2 Kindling was induced by once every 2 days treatment with PTZ (25 mg kg −1 i.p.) for 5 weeks. Challenge experiments were carried out after 15 or 30 days of last treatment with PTZ. 3 Administration of amiloride (2 h before PTZ, in doses of 0.65 and 1.3 mg kg −1 , p.o.) significantly prolonged the onset of kindling and reduced the incidence and severity of seizures in a dose‐dependent manner. The effect of amiloride on the incidence of PTZ‐induced seizures was evident even after 15 or 30 days of last treatment. 4 The results indicate a protective role for amiloride against PTZ‐induced kindling in mice. The possibility of mediation of such effects by NHE inhibition is discussed.British Journal of Pharmacology (2005) 145 , 880–884. doi: 10.1038/sj.bjp.0706291