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Cardioprotection with adenosine: ‘a riddle wrapped in a mystery’
Author(s) -
Przyklenk Karin,
Whittaker Peter
Publication year - 2005
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0706261
Subject(s) - adenosine , cardioprotection , paraphrase , myocardial reperfusion injury , medicine , ischemia , neuroscience , myocardial ischemia , psychology , philosophy , linguistics
Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: ‘I cannot forecast to you the action of adenosine . It is a riddle wrapped in a mystery inside an enigma’ . That is, although it is well‐established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion‐induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size. British Journal of Pharmacology (2005) 145 , 699–700. doi: 10.1038/sj.bjp.0706261