Cardioprotection with adenosine: ‘a riddle wrapped in a mystery’

Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: ‘I cannot forecast to you the action of adenosine . It is a riddle wrapped in a mystery inside an enigma’ . That is, although it is well‐established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion‐induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size. British Journal of Pharmacology (2005) 145 , 699–700. doi: 10.1038/sj.bjp.0706261