Platelet–cancer interactions: mechanisms and pharmacology of tumour cell‐induced platelet aggregation | Zendy

Jurasz Paul | Zendy; AlonsoEscolano David | Zendy; Radomski Marek W | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Platelet–cancer interactions: mechanisms and pharmacology of tumour cell‐induced platelet aggregation

Author(s) -

Jurasz Paul,

AlonsoEscolano David,

Radomski Marek W

Publication year - 2004

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0706013

Subject(s) - platelet , cancer cell , cancer , metastasis , platelet aggregation , pharmacology , cell , platelet aggregation inhibitor , platelet activation , cancer research , biology , medicine , chemistry , immunology , biochemistry

During haematogenous metastasis, cancer cells migrate to the vasculature and interact with platelets resulting in tumour cell‐induced platelet aggregation (TCIPA). We review:The biological and clinical significance of TCIPA; Molecular mechanisms involved in platelet aggregation by cancer cells; Strategies for pharmacological regulation of these interactions.We conclude that pharmacological regulation of platelet–cancer cell interactions may reduce the impact of TCIPA on cancer biology. British Journal of Pharmacology (2004) 143 , 819–826. doi: 10.1038/sj.bjp.0706013

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research