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The NAADP receptor: commentary on Billington et al .
Author(s) -
Galione A,
Parrington J,
Dowden J
Publication year - 2004
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0705888
Subject(s) - ryanodine receptor , sea urchin , receptor , second messenger system , calcium , biology , inositol , inositol trisphosphate receptor , calcium signaling , microbiology and biotechnology , biochemistry , chemistry , organic chemistry
NAADP is a recently described calcium‐mobilizing messenger. First discovered as a potent calcium‐releasing molecule in sea urchin eggs, its actions have now been reported in several mammalian cell types. In the sea urchin egg, NAADP‐sensitive calcium release channels appear distinct from inositol trisphosphate or ryanodine receptors, and are mainly localized to acidic compartments. In this study, Billington et al . extend the pharmacology of the putative NAADP receptor utilizing molecules unrelated to NAADP itself. This work may provide an important step in developing selective NAADP receptor modulators that will help define the role of NAADP in cell signalling. British Journal of Pharmacology (2004) 142 , 1203–1207. doi: 10.1038/sj.bjp.0705888