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Pharmacological prevention of cardiovascular aging – targeting the Maillard reaction
Author(s) -
Aronson Doron
Publication year - 2004
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0705832
Subject(s) - maillard reaction , ventricle , arterial stiffness , medicine , cardiology , heart failure , endocrinology , chemistry , biochemistry , blood pressure
The development of myocardial and large vessel stiffness with aging underlies the development of diastolic heart failure and isolated systolic hypertension. Nonenzymatic reaction between glucose and proteins (Maillard reaction) leading to collagen crosslinking in the myocardium and arterial wall has been implicated in age‐related increase in cardiovascular stiffness. In the present issue, Chang et al . show that aminoguanidine, an inhibitor of protein crosslinking, retards age‐related decline in the elastic properties of the left ventricle and arteries. The significance of these findings is discussed in this commentary. British Journal of Pharmacology (2004) 142 , 1055–1058. doi: 10.1038/sj.bjp.0705832