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Calcitonin gene‐related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine
Author(s) -
Brain Susan D
Publication year - 2004
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0705806
Subject(s) - calcitonin gene related peptide , migraine , calcitonin , antagonist , neuropeptide , vasodilation , medicine , pharmacology , endocrinology , receptor
The neuropeptide calcitonin gene‐related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has been largely assumed that the CGRP antagonist is effective due to its ability to block vasodilator activity. Goadsby and co‐workers present data that now suggest that CGRP antagonists may also block neuronal transmission in migraine. British Journal of Pharmacology (2004) 142 , 1053–1054. doi: 10.1038/sj.bjp.0705806