Hydrogen sulphide: an endogenous stimulant of capsaicin‐sensitive primary afferent neurons? | Zendy

Chahl L A | Zendy

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Hydrogen sulphide: an endogenous stimulant of capsaicin‐sensitive primary afferent neurons?

Author(s) -

Chahl L A

Publication year - 2004

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0705765

Subject(s) - capsaicin , afferent , endogeny , hydrogen sulphide , chemistry , stimulant , pharmacology , neuroscience , biochemistry , biology , receptor , sulfur , organic chemistry

Hydrogen sulphide (H 2 S) is a gas best known for its rotten egg smell. The toxic effects of high concentrations of H 2 S have been extensively investigated. It is known that H 2 S is generated in mammalian systems, but little is known of its effects in physiological concentrations. In the present issue of this journal, Patacchini et al . present evidence that H 2 S stimulates capsaicin‐sensitive primary afferent neurons to release tachykinins in the rat urinary bladder. The possible significance of this finding is discussed in this commentary. British Journal of Pharmacology (2004) 142 , 1–2. doi: 10.1038/sj.bjp.0705765

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