Premium
The anti‐relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine
Author(s) -
Mcgeehan Andrew J,
Olive M Foster
Publication year - 2003
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0705059
Subject(s) - acamprosate , conditioned place preference , conditioning , morphine , pharmacology , ethanol , psychology , saline , chemistry , anesthesia , medicine , naltrexone , antagonist , biochemistry , receptor , statistics , mathematics
The effects of the anti‐relapse compound acamprosate (calcium acetylhomotaurinate) on the conditioned rewarding effects of ethanol, cocaine and morphine were studied using the conditioned place preference (CPP) paradigm. During 3 days of drug conditioning, mice were pretreated with saline or acamprosate (30, 100 or 300 mg kg −1 i.p.) 10 min prior to the administration of ethanol (2 g kg −1 i.p.), cocaine (15 mg kg −1 i.p.) or morphine (10 mg kg −1 i.p.), and subsequently confined to one of two distinct conditioning chambers. On the following day, mice were tested for the expression of CPP. Acamprosate dose‐dependently reduced the development of CPP to ethanol and cocaine but not morphine. When tested as the conditioning drug, acamprosate alone produced neither a conditioned place preference nor aversion. These data suggest that acamprosate can suppress the conditioned rewarding effects of ethanol and certain classes of abused substances. British Journal of Pharmacology (2003) 138 , 9–12. doi: 10.1038/sj.bjp.0705059