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Unravelling mechanisms underlying ischaemic arrhythmias – the importance of models
Author(s) -
Guppy L J,
Walker M J A
Publication year - 2002
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0704976
Subject(s) - ischemia , myocardial ischaemia , coronary artery occlusion , medicine , cardiology , cerebral ischaemia , coronary occlusion , anesthesia
A new model of regional ischaemia using blood‐perfused isolated rat hearts is reported in this issue. This model has potential value in pharmacology to test the actions of drugs against the arrhythmias that arise early period (0–30 min) after induction of ischaemia. Unfortunately, the severity of arrhythmias in this new model is reduced, when compared to other models, in both the early and the late period (1–4 h) of coronary artery occlusion. This commentary compares the new model with previous models, and comments on the possible mechanisms of arrhythmias induced by ischaemia. British Journal of Pharmacology (2002) 137 , 941–942. doi: 10.1038/sj.bjp.0704976