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Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist
Author(s) -
Ishihara Akane,
Kanatani Akio,
Okada Megumu,
Hidaka Masayasu,
Tanaka Takeshi,
Mashiko Satoshi,
Gomori Akira,
Kanno Tetsuya,
Hata Mikiko,
Kanesaka Maki,
Tominaga Yushin,
Sato Nagaaki,
Kobayashi Masahiko,
Murai Takashi,
Watanabe Keiko,
Ishii Yasuyuki,
Fukuroda Takahiro,
Fukami Takehiro,
Ihara Masaki
Publication year - 2002
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0704696
Subject(s) - medicine , endocrinology , antagonist , neuropeptide y receptor , weight gain , corticosterone , neuropeptide , oral administration , receptor , receptor antagonist , obesity , chemistry , body weight , hormone
An experiment was conducted to examine whether a potent, orally active and highly selective neuropeptide Y Y 1 receptor antagonist attenuates hyperphagia and obesity in genetically obese Zucker fatty rats. Oral administration of the Y1 antagonist (30 and 100 mg kg −1 , once daily for 2 weeks) significantly suppressed the daily food intake and body weight gain in Zucker fatty rats accompanied with a reduction of fat cell size and plasma corticosterone levels. Despite the fact that food intake was gradually returned to near the control level, the body weight of the treated animals remained significantly less when compared to that of the controls for the duration of the treatment. These results suggest that the Y 1 receptor, at least in part, participate in pathophysiological feeding and/or fat accumulation observed in Zucker fatty rats. Y1 antagonists might be useful for the treatment of obesity.British Journal of Pharmacology (2002) 136 , 341–346; doi: 10.1038/sj.bjp.0704696