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[Gly 14 ]‐Humanin improved the learning and memory impairment induced by scopolamine in vivo
Author(s) -
Mamiya Takayoshi,
Ukai Makoto
Publication year - 2001
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0704429
Subject(s) - memory impairment , cholinergic , in vivo , neuroscience , presenilin , spontaneous alternation , alzheimer's disease , psychology , pharmacology , endocrinology , biology , disease , medicine , hippocampus , cognition , genetics
Humanin is a very recently discovered 24 amino acid linear polypeptide, which protects against cell death induced by either familial Alzheimer's disease mutant of amyloid precursor protein, presenilin‐1 or presenilin‐2 in vitro . However, it has remained uncertain whether humanin is a useful drug for the animal model of learning and memory deficit. In this study, we evaluated the effects of [Gly 14 ]‐humanin, a more potent humanin analogue, on the scopolamine HBr (1 mg kg −1 s.c.)‐induced impairment of spontaneous alternation behaviour in the Y‐maze, an index of short‐term memory in mice. [Gly 14 ]‐Humanin (1000 pmol 5 μl −1 i.c.v.) reversed the impairment without affecting the number of arm entries. These results suggest that (I) [Gly 14 ]‐humanin is a beneficial drug for the impairment of learning and memory and (II) it modulates the learning and memory function mediated via cholinergic systems in mice. British Journal of Pharmacology (2001) 134 , 1597–1599; doi: 10.1038/sj.bjp.0704429