Cannabinoid inhibition of the capsaicin‐induced calcium response in rat dorsal root ganglion neurones | Zendy

Millns Paul J | Zendy; Chapman Victoria | Zendy; Kendall David A | Zendy

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Cannabinoid inhibition of the capsaicin‐induced calcium response in rat dorsal root ganglion neurones

Author(s) -

Millns Paul J,

Chapman Victoria,

Kendall David A

Publication year - 2001

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0703919

Subject(s) - capsaicin , dorsal root ganglion , cannabinoid receptor , cannabinoid , cannabinoid receptor agonists , pharmacology , chemistry , agonist , trpv1 , inhibitory postsynaptic potential , neuroscience , receptor , medicine , sensory system , transient receptor potential channel , biology , biochemistry

Cannabinoids have marked inhibitory effects on somatosensory processing, which may arise from actions at both peripheral and central cannabinoid receptors. Here, the effect of a synthetic cannabinoid agonist HU210 on capsaicin‐evoked responses in adult rat dorsal root ganglion (DRG) neurones was studied. The vanilloid capsaicin produced a concentration‐related increase in intracellular calcium in DRG neurones, which was significantly inhibited by HU210 (1 μ M ). The cannabinoid CB 1 receptor antagonist SR141716A (1 μ M ) had no effect alone and did not influence the response to capsaicin but significantly reversed the inhibitory effect of HU210. These data indicate that DRG CB 1 receptors are functional and can inhibit nociceptive responses. British Journal of Pharmacology (2001) 132 , 969–971; doi: 10.1038/sj.bjp.0703919

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