Premium
Nedocromil sodium inhibits histamine‐induced itch and flare in human skin
Author(s) -
Ahluwalia Poonam,
McGill James I,
Church Martin K
Publication year - 2001
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0703852
Subject(s) - nedocromil sodium , nedocromil , histamine , histaminergic , flare , human skin , medicine , scratching , anesthesia , pharmacology , pathology , biology , materials science , respiratory disease , physics , alternative medicine , composite material , lung , astrophysics , genetics , placebo
This study was designed to test the hypothesis that nedocromil sodium inhibits sensory nerve function to reduce flare and itch in human skin. Nedocromil sodium (2%) or water (control) was introduced into the volar forearm skin of eight non‐atopic volunteers by iontophoresis (8 mC) and histamine (20 μl of 1 μ M and 300 n M ) injected intradermally 10 min later at the same site. Itch was assessed on a visual analogue scale every 20 s for 5 min. Weal and flare areas and mean blood flux within the flare were assessed by scanning laser Doppler imaging at 10 min. The results showed that nedocromil sodium reduced itch scores, totalled over 5 min, by ∼74.0% ( P <0.005) and flare areas by ∼65% ( P <0.03). Neither weal areas nor blood flux within were reduced. These data demonstrate that nedocromil sodium is effective in reducing neurogenic itch and flare in the skin. We suggest that its mechanism of action is modulation of sensory neurone activation or conduction in the skin. British Journal of Pharmacology (2001) 132 , 613–616; doi: 10.1038/sj.bjp.0703852