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Adrenomedullin inhibits spontaneous and bradykinin‐induced but not oxytocin‐ or prostaglandin F 2α ‐induced periodic contraction of rat uterus
Author(s) -
Yanagita Toshihiko,
Yamamoto Ryuichi,
Sugano Takashi,
Kobayashi Hideyuki,
Uezono Yasuhito,
Yokoo Hiroki,
Shiraishi Seiji,
Minami Shinichi,
Wada Akihiko
Publication year - 2000
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0703500
Subject(s) - bradykinin , oxytocin , adrenomedullin , uterus , contraction (grammar) , prostaglandin , endocrinology , medicine , uterine contraction , muscle contraction , chemistry , receptor
In isolated rat uterine strips, adrenomedullin (AM) inhibited the spontaneous periodic contraction in a concentration‐dependent manner (IC 50 =22.3±0.7 n M ). The inhibitory effect of AM was prevented by either AM 22–52 , a putative antagonist for AM receptors, or calcitonin gene‐related peptide (CGRP) 8–37 , a putative antagonist for CGRP receptors. AM also attenuated bradykinin (BK)‐induced periodic uterine contraction, which was blocked by AM 22–52 or CGRP 8–37 , whereas AM had no effect on the periodic contraction caused by oxytocin or prostaglandin F 2α (PGF 2α ). RT–PCR analysis showed that mRNAs for calcitonin receptor‐like receptor (CRLR), receptor‐activity‐modifying protein (RAMP)1, RAMP2 and RAMP3 were expressed in the rat uterus. These results demonstrate that AM selectively inhibits spontaneous and BK‐induced periodic contraction via activating receptors for AM and CGRP. British Journal of Pharmacology (2000) 130 , 1727–1730; doi: 10.1038/sj.bjp.0703500