Premium
Acute blood pressure effects of YC‐1‐induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats
Author(s) -
Rothermund Lars,
Friebe Andreas,
Paul Martin,
Koesling Doris,
Kreutz Reinhold
Publication year - 2000
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0703320
Subject(s) - soluble guanylyl cyclase , guanylate cyclase , blood pressure , chemistry , gucy2d , endocrinology , medicine , pharmacology , guanylate cyclase 2c , nitric oxide
We used YC‐1 as a pharmacological tool to investigate the short‐term blood pressure effects of NO‐independent activation of sGC in normotensive and hypertensive rats. Four groups of normotensive Wistar‐Kyoto rats were treated by i.v. injection with vehicle (V), YC‐1 (YC‐1), sodium nitroprusside (SNP), or YC‐1 and SNP (YC‐1+SNP). Hypertension was induced in four additional groups of WKY rats by 3 weeks of oral treatment with L ‐NAME. These animals were investigated with the same protocol as the normotensive animals: L ‐NAME/V, L ‐NAME/YC‐1, L ‐NAME/SNP, L ‐NAME/YC‐1+SNP. YC‐1 lowered mean arterial blood pressure (MAP) in normotensive and hypertensive animals similarly to SNP alone ( P <0.05, respectively). The combination of YC‐1 with SNP caused a strong decrease of MAP in both the hypertensive and normotensive animals ( P <0.05, respectively). SNP with YC‐1 also induced a pronounced cyclic GMP increase in the aorta. This study shows for the first time the blood pressure lowering potential of bimodal targeting of the NO‐sGC‐system. British Journal of Pharmacology (2000) 130 , 205–208; doi: 10.1038/sj.bjp.0703320