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Upregulation of bradykinin B1‐receptor expression after myocardial infarction
Author(s) -
Tschöpe Carsten,
HeringerWalther Silvia,
Koch Matthias,
Spillmann Frank,
Wendorf Michael,
Leitner Eszter,
Schultheiss HeinzPeter,
Walther Thomas
Publication year - 2000
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0703239
Subject(s) - bradykinin , downregulation and upregulation , myocardial infarction , ventricle , medicine , endocrinology , cardiology , receptor , infarction , chemistry , biochemistry , gene
To determine the influence of the myocardial infarction (MI) on bradykinin B1‐receptor (B1R) regulation, we studied its expression in the left ventricle (LV) after MI. Rats were submitted to a permanent occlusion of the left coronary artery. Six hours, 24 h and 6 days after MI or after sham operation, left ventricular pressure (LVP) and d P /d t max were measured. LV‐total RNA was extracted and B1R expression was analysed by a RNase‐protection assay (each group n =6). LVP and d P /d t max were impaired at all time points after MI. Basal B1R expression was not detectable in controls. Six hours after MI, the B1R expression was upregulated and reached a maximum 24 h after MI (4 fold vs 6 h). Six days post‐MI, B1R expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial B1R expression in an in vivo model of MI. British Journal of Pharmacology (2000) 129 , 1537–1538; doi: 10.1038/sj.bjp.0703239