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Harmane produces hypotension following microinjection into the RVLM: possible role of I 1 ‐imidazoline receptors
Author(s) -
Musgrave I F,
Badoer E
Publication year - 2000
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0703142
Subject(s) - rostral ventrolateral medulla , imidazoline receptor , microinjection , clonidine , chemistry , antagonist , pharmacology , receptor , medicine , endocrinology , blood pressure , heart rate
The β‐carboline, harmane (0.1–1.0 nmol) produces dose dependent hypotension when microinjected unilaterally into the rostral ventrolateral medulla (RVLM) of the anaesthetized rat. The potency of harmane on blood pressure is similar to that of the imidazoline, clonidine. The hypotensive effects of both clonidine and harmane are reversed by microinjection of the relatively I 1 ‐receptor selective antagonist efaroxan (20 nmol). These results are consistent with harmane acting at an I 1 ‐receptor in the RVLM. This is the first report of an endogenous ligand for I 1 ‐receptors that has central effects on blood pressure. British Journal of Pharmacology (2000) 129 , 1057–1059; doi: 10.1038/sj.bjp.0703142