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Functional studies in atrium overexpressing A 1 ‐adenosine receptors
Author(s) -
Neumann Joachim,
Vahlensieck Ute,
Boknik Peter,
Linck Bettina,
Lüss Hartmut,
Müller Frank U,
Matherne G Paul,
Schmitz Wilhelm
Publication year - 1999
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702963
Subject(s) - adenosine , chronotropic , adenosine a1 receptor , medicine , adenosine receptor , endocrinology , adenosine a3 receptor , agonist , purinergic signalling , chemistry , inotrope , atrium (architecture) , receptor , biology , heart rate , atrial fibrillation , blood pressure
Adenosine and the A 1 ‐adenosine receptor agonist R‐PIA, exerted a negative inotropic effect in isolated, electrically driven left atria of wild‐type mice. In left atria of mice overexpressing the A 1 ‐adenosine receptor, adenosine and R‐PIA exerted a positive inotropic effect. The positive inotropic effect of adenosine and R‐PIA in transgenic atria could be blocked by the A 1 ‐adenosine receptor antagonist DPCPX. In the presence of isoprenaline, adenosine exerted a negative inotropic effect in wild‐type atria but a positive inotropic effect in atria from A 1 ‐adenosine receptor overexpressing mice. The rate of beating in right atria was lower in mice overexpressing A 1 ‐adenosine receptors compared with wild‐type. Adenosine exerted comparable negative chronotropic effects in right atria from both A 1 ‐adenosine receptor overexpressing and wild‐type mice. A 1 ‐adenosine receptor overexpression in the mouse heart can reverse the inotropic but not the chronotropic effects of adenosine, implying different receptor‐effector coupling mechanisms.British Journal of Pharmacology (1999) 128 , 1623–1629; doi: 10.1038/sj.bjp.0702963