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Early increases in renal kallikrein secretion on administration of potassium or ATP‐sensitive potassium channel blockers in rats
Author(s) -
Fujita Tomoe,
Hayashi Izumi,
Kumagai Yuji,
Inamura Naoya,
Majima Masataka
Publication year - 1999
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702899
Subject(s) - potassium channel , diuretic , potassium channel blocker , potassium , medicine , endocrinology , secretion , channel blocker , glibenclamide , kidney , chemistry , pharmacology , calcium , organic chemistry , diabetes mellitus
This study aimed to examine whether administration of potassium or ATP‐sensitive potassium channel (K ATP channel) blockers caused early increases in renal kallikrein (KK) secretion. To clarify this mechanism, the effect on renal KK secretion of a K ATP channel blocker was compared with the effect resulting from use of an osmotic diuretic or volume load. Furthermore, the effect on potassium‐induced increases in renal KK secretion by an additional treatment using a K ATP channel blocker was examined. Lastly, the effect of a K ATP channel blocker on renal KK secretion was also examined in superfused slices of kidney cortex. Intravenous infusion of potassium augmented renal KK secretion within 30 min while urine volume increased gradually in both the potassium loading and control groups. Administration of the K ATP channel blocker, 4‐morpholinecarboximidine‐N‐1‐adamantyl‐N′‐cyclohexylhydrochloride (PNU‐37883A) or glibenclamide, caused a dose‐dependent increase in renal KK secretion. The concentration of KK in urine was higher in the PNU‐37883A group as compared to the osmotic‐diuretic or volume‐load group. PNU‐37883A had no additive effect on the potassium‐induced increase in renal KK secretion. Renal KK secretion increased in slices of kidney cortex incubated with PNU‐37883A within 10 min of superfusion. In conclusion, administration of both potassium and K ATP channel blockers induced early increases in renal KK secretion in the absence of the washout phenomenon. Potassium loading may have increased renal KK secretion through the same mechanism as the K ATP channel blocker.British Journal of Pharmacology (1999) 128 , 1275–1283; doi: 10.1038/sj.bjp.0702899