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Nociceptin (1–7) antagonizes nociceptin‐induced hyperalgesia in mice
Author(s) -
Sakurada Tsukasa,
Sakurada Shinobu,
Katsuyama Sou,
Sakurada Chikai,
TanNo Koichi,
Terenius Lars
Publication year - 1999
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702898
Subject(s) - nociceptin receptor , hyperalgesia , nociception , nop , pharmacology , chemistry , endocrinology , tail flick test , opioid peptide , medicine , anesthesia , opioid , receptor
Nociceptin and its N‐terminal fragment, nociceptin (1–7), were administered intrathecally (i.t.) into conscious mice. Nociceptin (3.0 fmol) produced a significant reduction in the nociceptive thermal threshold (hyperalgesia) measured as the tail‐flick and paw‐withdrawal responses. Nociceptin (1–7), injected i.t., at 150–1200 fmol had no significant effect. However, when nociceptin (1–7) (150–1200 fmol) was injected simultaneously with nociceptin (3.0 fmol), nociceptin‐induced hyperalgesia was significantly reduced. Analgesia induced by a high dose (1200 pmol) of nociceptin was not antagonized by co‐administration of nociceptin (1–7) (1200 fmol). These results suggest that N‐terminal fragments of nociceptin formed endogenously could modulate the hyperalgesic action of nociceptin in the spinal cord. British Journal of Pharmacology (1999) 128 , 941–944; doi: 10.1038/sj.bjp.0702898