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The recombinant 5‐HT 1A receptor: G protein coupling and signalling pathways
Author(s) -
Raymond John R,
Mukhin Yurii V,
Gettys Thomas W,
Garnovskaya Maria N
Publication year - 1999
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702723
Subject(s) - 5 ht5a receptor , receptor , interleukin 21 receptor , enzyme linked receptor , g protein coupled receptor , gabbr1 , biology , signal transduction , pharmacophore , microbiology and biotechnology , protease activated receptor 2 , estrogen related receptor gamma , transfection , biochemistry , gene , nuclear receptor , transcription factor
The 5‐hydroxytryptamine 5‐HT 1A receptor was one of the first G protein coupled receptors whose cDNA and gene were isolated by molecular cloning methods. Transfection of the cDNA of this receptor into cells previously bearing no 5‐HT receptors has resulted in the acquisition of large amounts of information regarding potential signal transduction pathways linked to the receptor, correlations of receptor structure to its various functions, and pharmacological properties of the receptor. Transfection studies with the 5‐HT 1A receptor have generated critical new information that might otherwise have been elusive. This information notably includes the discovery of unsuspected novel signalling linkages, the elucidation of the mechanisms of receptor desensitization, the refinement of models of the receptor pharmacophore, and the development of silent receptor antagonists, among others. The current review summarizes the most important studies of the recombinant 5‐HT 1A receptor in the decade since the identificiation of its cDNA. British Journal of Pharmacology (1999) 127 , 1751–1764; doi: 10.1038/sj.bjp.0702723