Characterization of airway and vascular responses in murine lungs | Zendy

Held HeinzDieter | Zendy; Martin Christian | Zendy; Uhlig Stefan | Zendy

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Characterization of airway and vascular responses in murine lungs

Author(s) -

Held HeinzDieter,

Martin Christian,

Uhlig Stefan

Publication year - 1999

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0702394

Subject(s) - bronchoconstriction , methacholine , histamine , vasoconstriction , lung , airway resistance , adenosine , medicine , serotonin , endocrinology , chemistry , anesthesia , airway , receptor , respiratory disease

We characterized the responses of murine airways and pulmonary vessels to a variety of endogenous mediators in the isolated perfused and ventilated mouse lung (IPL) and compared them with those in precision‐cut lung slices. Airways: The EC 50 (μ M ) for contractions of airways in IPL/slices was methacholine (Mch), 6.1/1.5>serotonin, 0.7/2.0>U46619 (TP‐receptor agonist), 0.1/0.06>endothelin‐1, 0.1/0.05. In the IPL, maximum increase in airway resistance (R L ) was 0.6, 0.4, 0.8 and 11 cmH 2 O s ml −1 , respectively. Adenosine (1 m M ), bombesin (100 μ M ), histamine (10 m M ), LTC 4 (1 μ M ), PAF (0.25 μ M ) and substance P (100 μ M ) had only weak effects (<5% of Mch) on R L . Vessels: The EC 50 (μ M ) for vasoconstriction in the IPL was LTC 4 , 0.06>U46619, 0.05

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