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Nitrergic neurotransmission mediates the non‐adrenergic non‐cholinergic responses in the clitoral corpus cavernosum of the rabbit
Author(s) -
Cellek Selim,
Moncada Salvador
Publication year - 1998
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702278
Subject(s) - clitoris , neurotransmission , endocrinology , medicine , inhibitory postsynaptic potential , erectile tissue , chemistry , tetrodotoxin , cgmp specific phosphodiesterase type 5 , adrenergic , neurotransmitter , nitric oxide , erectile dysfunction , anatomy , receptor
The corpus cavernosum is the erectile tissue in the penis and clitoris. Although nitrergic neurotransmission has been characterized in detail in the penile corpus cavernosum, functional studies on the inhibitory non‐adrenergic non‐cholinergic (NANC) transmission in the clitoral corpus cavernosum have been lacking. Here we demonstrate that electrical field stimulation (EFS) induces NANC relaxation responses in the clitoral corpus cavernosum of the rabbit. These responses were inhibited by N G ‐nitro‐ L ‐arginine methylester ( L ‐NAME), 1H‐[1,2,4]oxadiazolo[4,3,‐a]quinoxalin‐1‐one (ODQ) or tetrodotoxin. The inhibitory effect of L ‐NAME was partially reversed by L ‐arginine but not by D ‐arginine. EFS‐induced relaxations were enhanced by an inhibitor of type V cyclic GMP phosphodiesterase, zaprinast. These results suggest that nitrergic neurotransmission is responsible for the NANC relaxation responses in the clitoral corpus cavernosum of the rabbit.