Evidence that [Phe 1 ψ(CH 2 ‐NH)Gly 2 ]nociceptin‐(1‐13)‐NH 2 , a peripheral ORL‐1 receptor antagonist, acts as an agonist in the rat spinal cord | Zendy

Carpenter Kate J. | Zendy; Dickenson Anthony H. | Zendy

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Evidence that [Phe 1 ψ(CH 2 ‐NH)Gly 2 ]nociceptin‐(1‐13)‐NH 2 , a peripheral ORL‐1 receptor antagonist, acts as an agonist in the rat spinal cord

Author(s) -

Carpenter Kate J.,

Dickenson Anthony H.

Publication year - 1998

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0702188

Subject(s) - nociceptin receptor , agonist , antagonist , chemistry , electrophysiology , stereochemistry , receptor , opioid peptide , opioid , medicine , biochemistry

[Phe 1 ψ(CH 2 ‐NH)Gly 2 ]nociceptin‐(1‐13)‐NH 2 , a pseudopeptide analogue of nociceptin is an antagonist in peripheral assays. Here, using in vivo electrophysiological recordings of dorsal horn neurones, [Phe 1 ψ(CH 2 ‐NH)Gly 2 ]nociceptin‐(1‐13)‐NH 2 appears to have agonist activity after spinal administration. The noxious evoked activity of the neurones was inhibited by [Phe 1 ψ(CH 2 ‐NH)Gly 2 ]nociceptin‐(1‐13)‐NH 2 , which was as potent as nociceptin itself. British Journal of Pharmacology (1998) 125 , 949–952; doi: 10.1038/sj.bjp.0702188

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