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Venous versus arterial actions of diethylamine/nitric oxide (DEA/NO) complex and S‐nitroso‐N‐acetylpenicillamine (SNAP) in vivo
Author(s) -
Ng Sylvia S W,
Pang Catherine C Y
Publication year - 1998
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0702175
Subject(s) - mean circulatory filling pressure , snap , sodium nitroprusside , mean arterial pressure , chemistry , anesthesia , heart rate , blood pressure , nitric oxide , pharmacology , medicine , central venous pressure , computer graphics (images) , computer science
1 We studied the effects of diethylamine/NO complex (DEA/NO) and S‐nitroso‐N‐acetylpenicillamine (SNAP), relative to those of sodium nitroprusside (SNP) and nitroglycerin (NTG), on mean arterial pressure (MAP), mean circulatory filling pressure (MCFP), arterial resistance (R a ), venous resistance (R v ), heart rate (HR), cardiac output (CO) and stroke volume (SV) in groups of Inactin‐anaesthetized rats pre‐treated with i.v. mecamylamine (3.7 μmol kg −1 ) and noradrenaline (6.8 nmol kg −1 min −1 ). Doses of each that reduced MAP by 30%, 80% and the lowest dose that maximally reduced MAP were examined to allow a comparison of the compounds' dilator actions at equivalent effective depressor doses. 2 DEA/NO (4, 32 and 256 μg kg −1 min −1 ), SNAP (4, 32 and 256 μg kg −1 min −1 ) and SNP (8, 32 and 128 μg kg −1 min −1 ) caused similar dose‐dependent reductions in MAP and R a , and increases in CO and SV. NTG (0.2, 0.8 and 6.4 μg kg −1 min −1 ) dose‐dependently reduced R a , and increased CO and SV, but lowered MAP only at the highest dose. 3 DEA/NO, SNAP and SNP but not NTG lowered MCFP with efficacy: DEA/NO>SNAP>SNP. All four drugs reduced R v with efficacy: DEA/NO ≈amp; SNAP>SNP ≈amp; NTG. 4 Therefore, all compounds lowered R a and R v . DEA/NO, SNAP and SNP but not NTG reduced MCFP. The pharmacological profiles of DEA/NO and SNAP resemble SNP more than NTG.British Journal of Pharmacology (1998) 125 , 1247–1251; doi: 10.1038/sj.bjp.0702175