Premium
PYY‐preferring receptor in the dorsal vagal complex and its involvement in PYY stimulation of gastric acid secretion in rats
Author(s) -
Yang H.,
Li W. P.,
Reeve J. R.,
Rivier J.,
Taché Y.
Publication year - 1998
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701767
Subject(s) - peptide yy , endocrinology , medicine , gastric acid , pancreatic polypeptide , receptor , secretion , stimulation , biology , neuropeptide y receptor , microinjection , chemistry , neuropeptide , glucagon , hormone
Microinjection of peptide YY (PYY, 7–46 pmol) into the dorsal vagal complex (DVC) stimulated gastric acid secretion in urethane‐anaesthetized rats. Using a variety of neuropeptide Y (NPY) and PYY derivatives, we characterized the pharmacological profile of the receptor mediating the acid secretory response to PYY. [Pro 34 ]rat(r)/porcine(p)PYY and [Pro 34 ]human(h)PYY (23–117 pmol), microinjected unilaterally into the DVC resulted in a similar maximal increase in net acid secretion reaching 68±11 and 89±31 μmol 90 min −1 respectively. Rat/hNPY and pNPY (47 pmol) microinjected into the DVC induced a similar net gastric acid secretion (27±8 and 23±8 μmol 90 min −1 respectively) and a higher dose (116 pmol) tended to reduce the response. Pancreatic polypeptide (PP, 4–46 pmol), [Leu 31 ,Pro 34 ]r/hNPY (47 and 117 pmol) and the Y2 selective agonists, hPYY 3‐36 , pNPY 5‐36 and pNPY 13‐36 (25–168 pmol) microinjected into the DVC failed to influence basal gastric acid secretion. The rank order of potency of PYY[Pro 34 ]r/pPYY=[Pro 34 ]hPYY>r/hNPY=pNPY to stimulate gastric acid secretion upon injection into the DVC and the ineffectiveness of PP, [Leu 31 ,Pro 34 ]NPY and C‐terminal NPY/PYY fragments suggest that a PYY‐preferring receptor subtype may be involved in mediating the stimulating effect.British Journal of Pharmacology (1998) 123 , 1549–1554; doi: 10.1038/sj.bjp.0701767