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Effect of a monoclonal antibody against interleukin‐4 on collagen‐induced arthritis in mice
Author(s) -
Yoshino Shin
Publication year - 1998
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701607
Subject(s) - monoclonal antibody , arthritis , antibody , immunology , medicine , immunization , secretion , interleukin , type ii collagen , interferon gamma , cytokine , endocrinology
The present study was undertaken to investigate the effect of a monoclonal antibody (11B11 mAb) against interleukin‐4 (IL‐4) on collagen‐induced arthritis (CIA) in mice. 11B11 mAb was daily injected intraperitoneally over a period of 10 days, commencing on the day of immunization with type II collagen (CII). The results showed that the anti‐IL‐4 mAb markedly augmented both the incidence and the severity of CIA. The augmentation of the disease was associated with a significant increase in anti‐CII IgG2a antibody production, proliferative responses of lymph node cells to CII and interferon‐γ (IFN‐γ) secretion from the lymphoid cells. The production of anti‐CII IgG1 antibodies the secretion of IL‐4 was markedly reduced in the mAb‐treated mice. Thus, the neutralization of IL‐4 by 11B11 mAb appears to be effective in augmenting CIA.British Journal of Pharmacology (1998) 123 , 237–242; doi: 10.1038/sj.bjp.0701607