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Distinct inhibitory effects of spinal endomorphin‐1 and endomorphin‐2 on evoked dorsal horn neuronal responses in the rat
Author(s) -
Chapman Victoria,
Diaz Alvaro,
Dickenson Anthony H.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701594
Subject(s) - inhibitory postsynaptic potential , (+) naloxone , nociception , intrathecal , spinal cord , chemistry , pharmacology , neuroscience , medicine , opioid , receptor , anesthesia , biology
Intrathecal endomorphin‐1 and endomorphin‐2 (0.25–50 μg) dose‐relatedly reduced all components of electrical evoked C‐fibre responses of spinal neurones. These effects were partially reversed by naloxone. Endomorphin‐1, but not endomorphin‐2, dose‐relatedly reduced the Aβ‐fibre evoked responses. Peak inhibitory effects of endomorphin‐1 and −2 were at 15–20 min post‐administration. Thus spinal endomorphin‐2 had selective effects on noxious responses, whereas endomorphin‐1 was non‐selective.