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Evidence for the involvement of P 2 ‐purinoceptors in the cholinergic contraction of the guinea‐pig ileum
Author(s) -
Barthó Loránd,
Lénárd László,
Maggi Carlo A.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701350
Subject(s) - ppads , cholinergic , acetylcholine , purinergic receptor , suramin , endocrinology , medicine , contraction (grammar) , guinea pig , ileum , stimulation , atropine , muscle contraction , biology , chemistry , adenosine , receptor
In the isolated ileum of the guinea‐pig the P 2 ‐purinoceptor antagonists PPADS and suramin: (a) strongly inhibited the cholinergic contractile effect of α,β‐methylene ATP, (b) did not influence contractions evoked by exogenous acetylcholine (ACh) but, (c) moderately (by about 30%) inhibited cholinergic contractions due to electrical field stimulation (EFS), in a non‐additive manner. These results suggest that an endogenous ligand that stimulates P 2 ‐purinoceptors (possibly ATP) is involved in the contractile effect of EFS, as a positive modulator of ACh release. British Journal of Pharmacology (1997) 121 , 1507–1508; doi: 10.1038/sj.bjp.0701350