Premium
Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals
Author(s) -
Helyes Zsuzsanna,
Németh József,
Pintér Erika,
Szolcsányi János
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701209
Subject(s) - nociceptin receptor , neurogenic inflammation , calcitonin gene related peptide , antidromic , substance p , neuropeptide , stimulation , endocrinology , extravasation , neurotensin , bradykinin , medicine , free nerve ending , nociception , saphenous nerve , calcitonin , sensory nerve , chemistry , opioid peptide , anesthesia , opioid , sensory system , neuroscience , biology , receptor , immunology
Pretreatment with the novel neuropeptide nociceptin (20 μg kg −1 , i.p.) caused an inhibition of plasma extravasation evoked by antidromic stimulation of the saphenous nerve or by topical application of 1% mustard oil on the skin of the acutely denervated hindleg of the rat. In contrast, it did not affect non‐neurogenic inflammation evoked by s.c. injection of bradykinin after chronic denervation. Release of substance P (SP) and calcitonin gene‐related peptide (CGRP) from rat isolated tracheae in response to electrical field stimulation was diminished by nociceptin (100 n M ). It is concluded that nociceptin inhibits the release of sensory neuropeptides from terminals of nociceptive neurones. British Journal of Pharmacology (1997) 121 , 613–615; doi: 10.1038/sj.bjp.0701209