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Paradoxical action of the cannabinoid WIN 55,212‐2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices
Author(s) -
Maneuf Yannick P.,
Brotchie Jonathan M.
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701101
Subject(s) - globus pallidus , basal (medicine) , cannabinoid , endocrinology , neuroscience , cyclic gmp , medicine , chemistry , basal ganglia , biology , receptor , central nervous system , nitric oxide , insulin
The effects of the synthetic cannabinoid WIN 55,212‐2 on forskolin‐stimulated and basal adenosine 3′ : 5′‐cyclic monophosphate (cyclic AMP) accumulation in globus pallidus slices were investigated. WIN 55,212‐2 caused a concentration‐dependent decrease in forskolin‐stimulated cyclic AMP accumulation in globus pallidus slices (maximum inhibition 36% for 30 μ m ). This effect was blocked by the cannabinoid receptor antagonist SR 141716A (100 μ m ). WIN 55,212‐2 alone caused a concentration‐dependent increase in cyclic AMP levels in unstimulated slices (maximum increase 52.6% for 100 μ m ). This effect was also blocked by SR 141716A (100 μ m ). In either forskolin‐stimulated or unstimulated conditions SR 1417161A (100 μ m ) did not affect cyclic AMP levels. British Journal of Pharmacology (1997) 120 , 1397–1398; doi: 10.1038/sj.bjp.0701101