Paradoxical action of the cannabinoid WIN 55,212‐2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices | Zendy

Maneuf Yannick P. | Zendy; Brotchie Jonathan M. | Zendy

Premium

Paradoxical action of the cannabinoid WIN 55,212‐2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices

Author(s) -

Maneuf Yannick P.,

Brotchie Jonathan M.

Publication year - 1997

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1038/sj.bjp.0701101

Subject(s) - forskolin , medicine , endocrinology , cannabinoid , adenosine , globus pallidus , antagonist , stimulation , chemistry , cannabinoid receptor , cannabinoid receptor antagonist , biology , receptor , basal ganglia , central nervous system

The effects of the synthetic cannabinoid WIN 55,212‐2 on forskolin‐stimulated and basal adenosine 3′ : 5′‐cyclic monophosphate (cyclic AMP) accumulation in globus pallidus slices were investigated. WIN 55,212‐2 caused a concentration‐dependent decrease in forskolin‐stimulated cyclic AMP accumulation in globus pallidus slices (maximum inhibition 36% for 30 μ m ). This effect was blocked by the cannabinoid receptor antagonist SR 141716A (100 μ m ). WIN 55,212‐2 alone caused a concentration‐dependent increase in cyclic AMP levels in unstimulated slices (maximum increase 52.6% for 100 μ m ). This effect was also blocked by SR 141716A (100 μ m ). In either forskolin‐stimulated or unstimulated conditions SR 1417161A (100 μ m ) did not affect cyclic AMP levels. British Journal of Pharmacology (1997) 120 , 1397–1398; doi: 10.1038/sj.bjp.0701101

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research