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Naloxone‐insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea‐pig trachea by the novel opioid, nociceptin
Author(s) -
Patel Hema J,
Giembycz Mark A,
Spicuzza Lucia,
Barnes Peter J,
Belvisi Maria G
Publication year - 1997
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1038/sj.bjp.0701013
Subject(s) - damgo , nociceptin receptor , (+) naloxone , cholinergic , opioid peptide , acetylcholine , opioid , medicine , endocrinology , enkephalin , chemistry , opioid receptor , agonist , opioid antagonist , stimulation , pharmacology , receptor
The novel peptide, nociceptin and the μ‐opioid agonist [ d ‐Ala 2 , N‐Me‐Phe 4 , Gly 5 ‐ol]‐enkephalin (DAMGO) produced a concentration‐dependent inhibition of electrical field stimulation (EFS)‐evoked release of acetylcholine (ACh) from cholinergic nerves innervating guinea‐pig trachea. The non‐selective opioid receptor antagonist, naloxone, did not antagonize the inhibitory action of nociceptin under conditions where the inhibition of ACh release evoked by DAMGO was completely reversed. It is suggested that DAMGO and nociceptin can inhibit cholinergic, parasympathetic neurotransmission to the airways via the activation of classical (naloxone‐sensitive) and novel (naloxone‐insensitive) opioid receptors, respectively. British Journal of Pharmacology (1997) 120 , 735–736; doi: 10.1038/sj.bjp.0701013