Open AccessRNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls
Author(s) -
Susanna Zucca,
Stella Gagliardi,
Cecilia Pandini,
Luca Diamanti,
Matteo Bordoni,
Daisy Sproviero,
Maddalena Arigoni,
Martina Olivero,
Orietta Pansarasa,
Mauro Ceroni,
Raffaele Calogero,
Cristina Cereda
Publication year - 2019
Publication title -
scientific data
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.565
H-Index - 64
ISSN - 2052-4463
DOI - 10.1038/sdata.2019.6
Subject(s) - tardbp , amyotrophic lateral sclerosis , transcriptome , peripheral blood mononuclear cell , rna , gene , biology , computational biology , sod1 , disease , gene expression , medicine , genetics , pathology , in vitro
Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analysis on Peripheral Blood Mononuclear Cells (PBMCs) from sporadic and mutated ALS patients (mutations in FUS , TARDBP , SOD1 and VCP genes) and healthy controls. This dataset allows the whole-transcriptome characterization of PBMCs content, both in terms of coding and non-coding RNAs, in order to compare the disease state to the healthy controls, both for sporadic patients and for mutated patients. Our dataset is a starting point for the omni-comprehensive analysis of coding and lncRNAs, from an easy to withdraw, manage and store tissue that shows to be a suitable model for RNA profiling in ALS.