Open AccessOptimizing CARs for ocular delivery
Author(s) -
Anandani Nellan,
Terry J. Fry
Publication year - 2020
Publication title -
nature cancer
Language(s) - English
Resource type - Journals
ISSN - 2662-1347
DOI - 10.1038/s43018-020-00127-y
Subject(s) - retinoblastoma , chimeric antigen receptor , retina , cytokine , medicine , fusion protein , secretion , receptor , cancer research , delivery system , immunology , immunotherapy , biology , neuroscience , immune system , pharmacology , genetics , gene , recombinant dna
Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.