Open AccessHuman plasma proteomic profiles indicative of cardiorespiratory fitness
Author(s) -
Jeremy Robbins,
Bennet Peterson,
Daniela Schranner,
Usman A. Tahir,
Theresa Margarethe Rienmüller,
Shuliang Deng,
Michelle J. Keyes,
Daniel H. Katz,
Pierre M. Jean Beltran,
Jacob L. Barber,
Christian Baumgartner,
Steven A. Carr,
Sujoy Ghosh,
Changyu Shen,
Lori L. Jennings,
Robert Ross,
Mark A. Sarzynski,
Claude Bouchard,
Robert E. Gerszten
Publication year - 2021
Publication title -
nature metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.834
H-Index - 22
ISSN - 2522-5812
DOI - 10.1038/s42255-021-00400-z
Subject(s) - cardiorespiratory fitness , biomarker , vo2 max , cohort , medicine , bioinformatics , biology , heart rate , genetics , blood pressure
Maximal oxygen uptake (VO 2 max) is a direct measure of human cardiorespiratory fitness and is associated with health. However, the molecular determinants of interindividual differences in baseline (intrinsic) VO 2 max, and of increases of VO 2 max in response to exercise training (ΔVO 2 max), are largely unknown. Here, we measure ~5,000 plasma proteins using an affinity-based platform in over 650 sedentary adults before and after a 20-week endurance-exercise intervention and identify 147 proteins and 102 proteins whose plasma levels are associated with baseline VO 2 max and ΔVO 2 max, respectively. Addition of a protein biomarker score derived from these proteins to a score based on clinical traits improves the prediction of an individual's ΔVO 2 max. We validate findings in a separate exercise cohort, further link 21 proteins to incident all-cause mortality in a community-based cohort and reproduce the specificity of ~75% of our key findings using antibody-based assays. Taken together, our data shed light on biological pathways relevant to cardiorespiratory fitness and highlight the potential additive value of protein biomarkers in identifying exercise responsiveness in humans.