Open AccessSynthesis of Hydroxyapatite with Antibacterial Properties Using a Microwave-Assisted Combustion Method
Author(s) -
Suphatchaya Lamkhao,
Manlika Phaya,
Chutima Jansakun,
Nopakarn Chandet,
Kriangkrai Thongkorn,
Gobwute Rujijanagul,
Phuwadol Bangrak,
Chamnan Randorn
Publication year - 2019
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-019-40488-8
Subject(s) - crystallinity , radical , x ray photoelectron spectroscopy , dpph , antibacterial activity , electron paramagnetic resonance , materials science , combustion , nuclear chemistry , microwave , antioxidant , chemistry , bacteria , chemical engineering , organic chemistry , composite material , nuclear magnetic resonance , biology , physics , engineering , genetics , quantum mechanics
The prevention of implant-associated infections has been increasing clinically in orthopedic surgery. Hydroxyapatite with antibacterial properties was synthesized using a microwave-assisted combustion method. High crystallinity at low temperature can be achieved using this method. The synthesized hydroxyapatite exhibited a superior clear zone for both Gram-positive and Gram-negative bacteria. Electron spin resonance (ESR) and X-ray photoelectron spectroscopy (XPS) were used for the radical investigation. The application of intelligent ink testing and an antioxidant assay using DPPH reduction were also used to confirm the existence of radicals. These techniques provided data confirming that radicals are responsible for the antibacterial properties. The synthesized antibacterial hydroxyapatite would be a good candidate for the prevention any infection with medical implants and injection materials causing failure in bone repair.