Open AccessPrevalence and serogroup changes of Neisseria meningitidis in South Korea, 2010–2016
Author(s) -
Hyukmin Lee,
Younghee Seo,
Kyung Hyo Kim,
Kyungwon Lee,
Kang Won Choe
Publication year - 2018
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-018-23365-8
Subject(s) - neisseria meningitidis , microbiology and biotechnology , meropenem , ceftriaxone , penicillin , medicine , ampicillin , multilocus sequence typing , ciprofloxacin , meningitis , serotype , cefoxitin , rifampicin , antibiotics , virology , biology , bacteria , antibiotic resistance , pediatrics , genotype , biochemistry , genetics , gene , staphylococcus aureus
Determination of the major serogroups is an important step for establishing a vaccine programme and management strategy targeting Neisseria meningitidis . From April 2010 to November 2016, a total of 25 N. meningitidis isolates were collected in South Korea, in collaboration with the Korean Society of Clinical Microbiology. Among isolates, 19 isolates were recovered from blood and/or cerebrospinal fluid (CSF) in 46 patients who suffered from invasive meningococcal disease (IMD), and six isolates were found in sputum or the throat. The most common serogroup was serogroup B (overall, 36%, n = 9/25; IMD, 37%, n = 7/19), which was isolated in every year of the research period except for 2011. There were five serogroup W isolates recovered from patients in military service. W was no longer isolated after initiation of a vaccine programme for military trainees, but serogroup B caused meningitis in an army recruit training centre in 2015. In MLST analysis, 14 sequence types were found, and all isolates belonging to W showed the same molecular epidemiologic characteristics (W:P1.5-1, 2-2:F3-9:ST-8912). All isolates showed susceptibility to ceftriaxone, meropenem, ciprofloxacin, minocycline, and rifampin; however, the susceptibility rates to penicillin and ampicillin for isolates with W and C capsules were 22% and 30%, respectively.