Open AccessTumor-infiltrating CD45RO+ Memory T Lymphocytes Predict Favorable Clinical Outcome in Solid Tumors
Author(s) -
Guoming Hu,
Shimin Wang
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-017-11122-2
Subject(s) - colorectal cancer , infiltration (hvac) , hepatocellular carcinoma , solid tumor , stage (stratigraphy) , oncology , medicine , pathology , tumor infiltrating lymphocytes , cancer , biology , immunotherapy , paleontology , physics , thermodynamics
The prognostic role of tumor-infiltrating CD45RO + memory T lymphocytes (CD45RO + T cells) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 25 published studies with 4720 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD45RO + T cells in human solid tumors. We found that CD45RO + T cell infiltration was significantly associated with improved overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, CD45RO + T cell infiltration significantly improved 1-year, 3-year and 5-year OS in colorectal, gastric and esophageal cancer, but only 5-year OS in hepatocellular carcinoma. And these cells were positively associated with 1-year, 3-year and 5-year DFS in hepatocellular, colorectal and esophageal cancer. In addition, high density of intratumoral CD45RO + T cells inversely correlated with TNM stage of solid tumor. In conclusion, CD45RO + memory T lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances.