Open AccessCDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes
Author(s) -
Danhong Peng,
Jie Wang,
Rong Zhang,
Feng Jiang,
Claudia H.T. Tam,
Guozhi Jiang,
Tao Wang,
Miao Chen,
Jun Yan,
Shiyun Wang,
Dandan Yan,
Zhen He,
Rong Ma,
Yuqian Bao,
Cheng Hu,
Weiping Jia
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-017-09010-w
Subject(s) - medicine , type 2 diabetes , diabetes mellitus , diabetic retinopathy , single nucleotide polymorphism , cohort , population , bonferroni correction , gastroenterology , endocrinology , genotype , genetics , biology , gene , statistics , mathematics , environmental health
Diabetic retinopathy (DR) is a major microvascular complication of diabetes. Susceptibility genes for type 2 diabetes may also impact the susceptibility of DR. This case-control study investigated the effects of 88 type 2 diabetes susceptibility loci on DR in a Chinese population with type 2 diabetes performed in two stages. In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were significantly associated with DR. The association between CDKAL1 rs7756992 and DR remained significant after Bonferroni correction for multiple comparisons (corrected P = 0.0492). Then, the effect of rs7756992 on DR were analysed in two independent cohorts for replication in stage 2. Cohort (1) consisted of 380 patients with DR and 613 patients with diabetes for ≥5 years but without DR. Cohort (2) consisted of 545 patients with DR and 929 patients with diabetes for ≥5 years but without DR. A meta-analysis combining the results of stage 1 and 2 revealed a significant association between rs7756992 and DR, with the minor allele A conferring a lower risk of DR (OR 0.824, 95% CI 0.743–0.914, P = 2.46 × 10 −4 ).