Open AccessThe protein and mRNA expression levels of glial cell line-derived neurotrophic factor in post stroke depression and major depressive disorder
Author(s) -
Yanran Zhang,
Hanyang Jiang,
Yingying Yue,
Yingying Yin,
Yuqun Zhang,
Jinfeng Liang,
ShengHua Li,
Jun Wang,
Jianxin Lü,
Deqin Geng,
Aiqin Wu,
Yonggui Yuan
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-017-09000-y
Subject(s) - glial cell line derived neurotrophic factor , post stroke depression , hamd , neurotrophic factors , medicine , receiver operating characteristic , major depressive disorder , depression (economics) , biomarker , endocrinology , psychology , biology , receptor , hippocampus , significant difference , amygdala , biochemistry , macroeconomics , economics
Previous studies have indicated that the level of glial cell line-derived neurotrophic factor (GDNF) may be correlated with stroke and depression. Here, we investigated whether GDNF can be a discriminant indicator for post stroke depression (PSD). 159 participants were divided into four groups: PSD, stroke without depression (Non-PSD), major depressive disorder (MDD) and normal control (NC) group, and the protein and mRNA expression levels of GDNF in serum were measured. The results showed that only MDD group had statistical difference in protein and mRNA levels compared with the other three groups (Bonferroni test, P < 0.05). The results of receiver operating curve (ROC) analysis supported GDNF as general distinguishing models in PSD and MDD groups with the area under the curve (AUC) at 0.797 ( P < 0.001) and 0.831 ( P < 0.001) respectively. In addition, the Spearman analysis demonstrated that the GDNF protein level negatively correlated with the value of Hamilton depression rating scale (HAMD) in PSD patients (correlation coefficient = −0.328, P = 0.047). Together, these findings suggest the protein and mRNA expression levels of GDNF decreased in patients with depression. GDNF may serve as a potential biomarker for differential diagnosis of PSD from MDD patients.