Open AccessGraphene microfiber as a scaffold for regulation of neural stem cells differentiation
Author(s) -
Weibo Guo,
Jichuan Qiu,
Jingquan Liu,
Hong Li
Publication year - 2017
Publication title -
scientific reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.24
H-Index - 213
ISSN - 2045-2322
DOI - 10.1038/s41598-017-06051-z
Subject(s) - microfiber , scaffold , neural tissue engineering , neural stem cell , materials science , nanoporous , nanotechnology , regenerative medicine , graphene , tissue engineering , adhesion , stem cell , microbiology and biotechnology , biomedical engineering , biology , composite material , medicine
We report the cytocompatibility and regulating effects of the nanostructured reduced graphene oxide (rGO) microfibers, which are synthesized through a capillary hydrothermal method, on neural differentiation of neural stem cells (NSCs). Our findings indicate that the flexible, mechanically strong, surface nanoporous, biodegradable, and cytocompatible nanostructured rGO microfibers not only offer a more powerful substrate for NSCs adhesion and proliferation compared with 2D graphene film and tissue cluture plate but also regulate the NSCs differentiation into neurons and form a dense neural network surrounding the microfiber. These results illustrate the great potential of nanostructured rGO microfibers as an artificial neural tissue engineering (NTE) scaffold for nerve regeneration.