Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks | Zendy

Michael Ansorge | Zendy; Jiranuwat Sapudom | Zendy; Marina Chkolnikov | Zendy; W.D. Martin | Zendy; Ulf Anderegg | Zendy; Stephanie Möller | Zendy; Matthias Schnabelrauch | Zendy; W. Pompe | Zendy

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Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks

Author(s) -

Michael Ansorge,

Jiranuwat Sapudom,

Marina Chkolnikov,

W.D. Martin,

Ulf Anderegg,

Stephanie Möller,

Matthias Schnabelrauch,

W. Pompe

Publication year - 2017

Publication title -

scientific reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.24

H-Index - 213

ISSN - 2045-2322

DOI - 10.1038/s41598-017-05912-x

Subject(s) - paracrine signalling , myofibroblast , microbiology and biotechnology , transforming growth factor , chemistry , cellular differentiation , regulator , extracellular matrix , matrix (chemical analysis) , biology , fibrosis , pathology , medicine , receptor , biochemistry , gene , chromatography

TGFβ1 is a key regulator for induction of tissue remodeling after dermal wounding. We present a model of paracrine delivery of TGFβ1 for differentiation of dermal fibroblasts based on a fibrillar 3D collagen matrix and embedded TGFβ1 releasing microparticles. We found differentiation into myofibroblasts was achieved in a TGFβ1 dependent manner at much lower doses than systemic delivery. This effect is accounted to the slow and sustained TGFβ1 release mimicking paracrine cell signals.

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