Open AccessRNA-modifying enzymes and their function in a chromatin context
Author(s) -
Konstantinos Tzelepis,
Oliver Rausch,
Tony Kouzarides
Publication year - 2019
Publication title -
nature structural and molecular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.448
H-Index - 270
eISSN - 1545-9993
pISSN - 1545-9985
DOI - 10.1038/s41594-019-0312-0
Subject(s) - chromatin , rna , computational biology , function (biology) , context (archaeology) , biology , chia pet , enzyme , microbiology and biotechnology , genetics , gene , chromatin remodeling , biochemistry , paleontology
Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.