Open AccessOpponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state
Author(s) -
Scott S. Bolkan,
Iris R. Stone,
Lucas Pinto,
Zoe Ashwood,
Jorge M. Iravedra Garcia,
Alison L Herman,
Priyanka Singh,
Akhil Bandi,
Julia Cox,
Christopher A Zimmerman,
Jounhong Ryan Cho,
Ben Engelhard,
Jonathan W Pillow,
Ilana B. Witten
Publication year - 2022
Publication title -
nature neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.403
H-Index - 422
eISSN - 1546-1726
pISSN - 1097-6256
DOI - 10.1038/s41593-022-01021-9
Subject(s) - neuroscience , task (project management) , striatum , cognition , psychology , control (management) , indirect pathway of movement , internal model , motor control , direct pathway of movement , cognitive psychology , computer science , dopamine , artificial intelligence , management , economics
A classic view of the striatum holds that activity in direct and indirect pathways oppositely modulates motor output. Whether this involves direct control of movement, or reflects a cognitive process underlying movement, remains unresolved. Here we find that strong, opponent control of behavior by the two pathways of the dorsomedial striatum depends on the cognitive requirements of a task. Furthermore, a latent state model (a hidden Markov model with generalized linear model observations) reveals that-even within a single task-the contribution of the two pathways to behavior is state dependent. Specifically, the two pathways have large contributions in one of two states associated with a strategy of evidence accumulation, compared to a state associated with a strategy of repeating previous choices. Thus, both the demands imposed by a task, as well as the internal state of mice when performing a task, determine whether dorsomedial striatum pathways provide strong and opponent control of behavior.