Open AccessNew oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination
Author(s) -
Sarah A Neely,
J Williamson,
Anna Klingseisen,
Lida Zoupi,
Jason J Early,
Anna Williams,
David A. Lyons
Publication year - 2022
Publication title -
nature neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.403
H-Index - 422
eISSN - 1546-1726
pISSN - 1097-6256
DOI - 10.1038/s41593-021-01009-x
Subject(s) - multiple sclerosis , neuroscience , oligodendrocyte , myelin , zebrafish , regeneration (biology) , biology , remyelination , demyelinating disorder , myelin sheath , microbiology and biotechnology , central nervous system , immunology , biochemistry , gene
Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS.