Open AccessSingle-cell analysis of olfactory neurogenesis and differentiation in adult humans
Author(s) -
Michael A. Durante,
Stefan Kurtenbach,
Zoukaa Sargi,
J. William Harbour,
Rhea Choi,
Sarah Kurtenbach,
Garrett M. Goss,
Hiroaki Matsunami,
Bradley J. Goldstein
Publication year - 2020
Publication title -
nature neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.403
H-Index - 422
eISSN - 1546-1726
pISSN - 1097-6256
DOI - 10.1038/s41593-020-0587-9
Subject(s) - neuroepithelial cell , neurogenesis , neuroscience , biology , neural stem cell , olfactory system , olfactory bulb , neuron , olfactory ensheathing glia , olfactory receptor , stem cell , central nervous system , microbiology and biotechnology
The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.