Open AccessA cerebello-olivary signal for negative prediction error is sufficient to cause extinction of associative motor learning
Author(s) -
Olivia A. Kim,
Shogo Ohmae,
Javier F. Medina
Publication year - 2020
Publication title -
nature neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 13.403
H-Index - 422
eISSN - 1546-1726
pISSN - 1097-6256
DOI - 10.1038/s41593-020-00732-1
Subject(s) - neuroscience , optogenetics , extinction (optical mineralogy) , gabaergic , motor learning , psychology , associative learning , associative property , inhibitory postsynaptic potential , biology , paleontology , mathematics , pure mathematics
The brain generates negative prediction error (NPE) signals to trigger extinction, a type of inhibitory learning that is responsible for suppressing learned behaviors when they are no longer useful. Neurons encoding NPE have been reported in multiple brain regions. Here, we use an optogenetic approach to demonstrate that GABAergic cerebello-olivary neurons can generate a powerful NPE signal, capable of causing extinction of conditioned motor responses on its own.