Open AccessAutoimmunity and organ damage in systemic lupus erythematosus
Author(s) -
George C. Tsokos
Publication year - 2020
Publication title -
nature immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.074
H-Index - 388
eISSN - 1529-2916
pISSN - 1529-2908
DOI - 10.1038/s41590-020-0677-6
Subject(s) - autoimmunity , epigenetics , immune system , immunology , biology , systemic lupus erythematosus , innate immune system , acquired immune system , inflammation , organ system , systemic inflammation , lupus erythematosus , medicine , genetics , disease , gene , antibody , pathology
Impressive progress has been made over the last several years toward understanding how almost every aspect of the immune system contributes to the expression of systemic autoimmunity. In parallel, studies have shed light on the mechanisms that contribute to organ inflammation and damage. New approaches that address the complicated interaction between genetic variants, epigenetic processes, sex and the environment promise to enlighten the multitude of pathways that lead to what is clinically defined as systemic lupus erythematosus. It is expected that each patient owns a unique 'interactome', which will dictate specific treatment.