Open AccessRegulatory T cells in autoimmune disease
Author(s) -
Margarita DominguezVillar,
David A. Hafler
Publication year - 2018
Publication title -
nature immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.074
H-Index - 388
eISSN - 1529-2916
pISSN - 1529-2908
DOI - 10.1038/s41590-018-0120-4
Subject(s) - autoimmunity , peripheral tolerance , immunology , autoimmune disease , immune system , biology , disease , immune tolerance , treg cell , t cell , medicine , il 2 receptor , antibody , pathology
In recent years, the understanding of regulatory T cell (T reg cell) biology has expanded considerably. Key observations have challenged the traditional definition of T reg cells and have provided insight into the underlying mechanisms responsible for the development of autoimmune diseases, with new therapeutic strategies that improve disease outcome. This Review summarizes the newer concepts of T reg cell instability, T reg cell plasticity and tissue-specific T reg cells, and their relationship to autoimmunity. Those three main concepts have changed the understanding of T reg cell biology: how they interact with other immune and non-immune cells; their functions in specific tissues; and the implications of this for the pathogenesis of autoimmune diseases.