Open AccessSalmonella Typhimurium and inflammation: a pathogen-centric affair
Author(s) -
Jorge E. Galán
Publication year - 2021
Publication title -
nature reviews. microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 11.496
H-Index - 300
eISSN - 1740-1534
pISSN - 1740-1526
DOI - 10.1038/s41579-021-00561-4
Subject(s) - biology , salmonella enterica , innate immune system , effector , immune system , microbiology and biotechnology , salmonella , inflammation , pathogen , intestinal epithelium , pattern recognition receptor , type three secretion system , pathogenicity island , receptor , secretion , immunology , bacteria , virulence , epithelium , gene , genetics , biochemistry
Microbial infections are controlled by host inflammatory responses that are initiated by innate immune receptors after recognition of conserved microbial products. As inflammation can also lead to disease, tissues that are exposed to microbial products such as the intestinal epithelium are subject to stringent regulatory mechanisms to prevent indiscriminate signalling through innate immune receptors. The enteric pathogen Salmonella enterica subsp. enterica serovar Typhimurium, which requires intestinal inflammation to sustain its replication in the intestinal tract, uses effector proteins of its type III secretion systems to trigger an inflammatory response without the engagement of innate immune receptors. Furthermore, S. Typhimurium uses a different set of effectors to restrict the inflammatory response to preserve host homeostasis. The S. Typhimurium-host interface is a remarkable example of the unique balance that emerges from the co-evolution of a pathogen and its host.